“DL” Dialysis Loop probes have been designed for both in vivo studies (subcutaneous tissue, peritoneal cavity, etc.) in experimental animals and in vitro studies in aqueous solutions (tissue homogenates, cell suspensions, plasma, biological fluids). Although the profile of a DL microdialysis probe is thicker than the “LM” Linear Microdialysis Probe, it is a stronger probe with more reinforcement at the membrane/tubing joint. DL microdialysis probes also offer a longer membrane lengths than LM probes.

The DL microdialysis probe is also a good choice for many in vitro applications, teaching, and first-time users.  While the DL probe is referred to as a microdialysis loop probe, as shown in the figure above, the DL probe may be used as a linear probe (A), or folded in half to form a microdialysis loop (B). A small slice of plastic tubing can be used to secure the loop (C) with the glue joints staggered to minimize the thickness of the looped probe.

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Overview

Name	DL-1, Loop Microdialysis Probe, 1cm membrane DL-2, Loop Microdialysis Probe, 2cm membrane DL-3, Loop Microdialysis Probe, 3cm membrane DL-5, Loop Microdialysis Probe, 5cm membrane
Part Number	MF-7049, DL-1 MF-7050, DL-2 MF-7052, DL-3 MF-7051, DL-5
Tubing	Flexible, ~1.2mm OD at thickest point, inert biocompatible plastic, 16 cm FEP tubing on each side of membrane for all probe lengths.
Probe Volume	DL-1, 6.5 µL DL-2, 6.9 µL DL-3, 7.3 µL DL-5, 8.0 µL
Use	Best for large or active animals. Compared to other microdialaysis probes, the DL’s longer membrane lengths offer higher relative recoveries. A stainless-steel wire reinforces the membrane to prevent crimping. Can be used as a linear probe or gently folded to form a loop. Can be implanted with 16G needle.
Membrane	PAN. 30KDa MWCO, 320 µm OD, membrane is reinforced with stainless steel guide wire.
Dimensions	Membrane	OD 320µm	ID 240µm
	Joint Tubing	OD 1.0mm
	Tubing	OD 635µm	ID 102µm

Loop Microdialysis Probes